CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.

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CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide

CD11c/CD18 is a member of the leukocyte integrin family, heterodimeric adhesion molecules that interact with a diverse repertoire of ligands, including bacterial lipopolysaccharide (LPS). Their role as signal transducing receptors remains uncertain. We used a heterologous expression system to determine if CD11c/CD18 was capable of initiating signal transduction in response to LPS-binding, as as...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1995

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.181.4.1473